Polymorphonuclear Leukocytes in Immunologic Reactions

A Role of Polymorphonuclear Leukocytes

In acute immunologic injury of tissues one of the common features noted is the accumulation of polymorphonuclear leukocytes (polymorphs) along w i t h antigen, antibody, and host complement (C') at the site of damage. This has been noted in venules of the Arthus phenomenon, in arteries in serum sickness, and in glomeruli of acute nephritis both in experimental animals and in human beings. In ea...

A Comparison of the Effects on the Shwartzman Phenomenon of Leukopenia Produced by Nitrogen Mustard and by Whole Body Irradiation

The effect of leukopenia on the susceptibility of rabbits to the localized Shwartzman reaction was studied in those receiving whole body irradiation and nitrogen mustard respectively. Of animals receiving nitrogen mustard in which the total polymorphonuclear leukocyte count was less than 100 cells/c.mm. only 17 per cent developed positive local Shwartzman reactions whereas 75 per cent of irradi...

Nuclear segmentation, condensation and bilateral symmetry in polymorphonuclear leukocytes reflect genomic order and favor immunologic function.

Segmentation, condensation and bilateral symmetry of the nuclei of polymorphonuclear leukocytes seem related to their function. Segmentation of the nuclei into two or more lobes and their condensation facilitate their passage (diapedesis) through the endothelial layer of blood vessels to the extravasal space and subsequent locomotion through the interstitial compartment of different tissues. Bi...

The mechanism of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits.

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

The role of superoxide anion- and myeloperoxidase-dependent reactions in the light emission by phagocytosing polymorphonuclear leukocytes has been investigated using leukocytes that lack myeloperoxidase, inhibitors (azide, superoxide dismutase), and model systems. Our earlier finding that oxygen consumption, glucose C-1 oxidation, and formate oxidation are greater in polymorphonuclear leukocyte...